There is a potential change in Ebola vaccine against the deadly virus which has led to 100% preliminary protection results, which could be a “Game-Changer”.
There were no proven drugs or vaccines against the virus at the start of the largest outbreak of Ebola in history, which began in Guinea in December 2013.
The World Health Organization (WHO) said the findings, being published in the Lancet, could be a “Game-Changer” which results were “remarkable”.
This remarkable result centred on the VSV-EBOV vaccine, which started by the Public Health Agency of Canada and then developed by the pharmaceutical company Merck.
It combined a fragment of the Ebola virus with another safer virus in order to train the immune system to beat the virus.
A unique clinical trial took place in Guinea. When a patient was discovered, their friends, neighbours and family were vaccinated to create a “protective ring” of immunity.
This could be the breakthrough the world has been waiting for.
There is caution as the results are still preliminary, with more data coming in.
But officials at the WHO believe the effectiveness of the vaccine will end up being between 75% and 100%.
If such a vaccine was available 18 months ago then thousands of lives could have been saved.
In the 2,014 close contacts who were vaccinated immediately there were no subsequent cases of Ebola.
In those vaccinated later there were 16 cases, according to the results published in the Lancet medical journal.
WHO says it is so far 100% effective, although that figure may change as more data is collected.
Close contacts of Ebola patients in Guinea will now be vaccinated immediately. And since the vaccine has been shown to be safe, that process will also be extended to include children.
Médecins sans Frontières (MSF) is involved with this research, and is part of a parallel trial for frontline healthcare workers.
Medical director Bertrand Draguez said the Lancet results should spur instant action.
“With such high efficacy, all affected countries should immediately start and multiply ring vaccinations to break chains of transmission and vaccinate all front line workers to protect them.”