Donald Trump campaign manager Corey Lewandowski is to leave his job as reported by campaign spokeswoman that he would no longer be working with the campaign team.
The exact reason for Mr. Lewandowski’s departure is not yet clear.
“The campaign is grateful to Corey for his hard work and dedication and we wish him the best in the future.”
The New York Times said the campaign was planning adjustments to the needs of the general election campaign.
His departure comes as Donald Trump, faces strong resistance from senior members of his own party over his strident tone and his hard line immigration policy.
Trump has been criticised for his reaction to the Orlando nightclub shooting in which 49 people were killed.
Following the shooting, Trump repeated his pledge that the US should ban Muslims from entering the country.
Republicans also started to distance themselves from him following his personal attacks against a Hispanic federal judge overseeing two lawsuits against him.
Mr Lewandowski has had a contentious relationship with the press. Earlier this year, he was charged with battery after allegedly yanking a female reporter out of Mr. Trump’s way after a campaign event.
Donald Trump defended him throughout that incident, which concluded when the charges were dropped. One Trump campaign director, Michael Caputo, tweeted “Ding dong the witch is dead” following the news.
Mr. Lewandowski did not get along with Trump chief strategist Paul Manafort either, with sources telling the New York Times that he would try to block Mr. Manafort from hiring more campaign staff.
Donald Trump is suffering in political polls lately, with most voters viewing him as “strongly unfavorable”.